This is a chance. I have experienced vehicles with the 5.4L having the same problem. However, it wasn't the coil that was bad, it was the rubber boot that connects to the plug. Check the boot very closely. If there is a weak point in the boot, it will arc and cause a misfire. Check closely for light gray spots in the boot that would indicate the problem.
Also, the code you got leads me to believe that you have a bad coil. I want you to switch it with any of the others that you know are good to see if the misfire chances cylenders.
Let me know what you find.
Joe
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Saturday, February 27th, 2010 AT 11:20 PM