Engine misfire? I've been getting the P0301 code?

Thank you for the follow up madmike1735.

I had replaced the original coil pack with an aftermarket couple of years ago as a "routine maintenance". The original coil was working fine so I had kept it as spare. When misfire started, I first swaped with the original coil that I had kept and then got another brand new one. Both swaps didn't fix the problem.

Regarding spark check, I used an inline spark tester that flashes and things looked ok. I then decided to do an alternate check by pulling the wires and holding them close to the spark plug tip. My plugs sit between exhaust manifold and what I noticed was that bright white sparks arced to the manifold in a circulation on each fire on cylinder 2 4 and 5. On the other three cylinders I saw small bright white arc going between wire and spark plug tip. When I turned the a/c on (this is when misfire is most obvious) and reved the engine, sparks on 1 and 6 disappeared. I didn't check 3, but I think its safe to say that it lost the spark. As well.

I have checked and rechecked for cross wiring. My wires and coil have numbers on them so its difficult to make mistake.

I was considering replacing crankshaft position sensor but something tells me that's not the problem. Mostly when crank sensor fails, there is no spark on all cylinders.

The van shudders badly over 40; you can't drive the thing so I am baffled why its not setting at least some code.

It makes sense but I don't know where to go from here and what to eliminate besides throwing parts.

Wanted to post the find for others. The coil wasn't the problem. In the end, it turned out to be a bad spark plug. Still don't know why no misfire code was being set but then I am no expert on how the computer system works.

Thanks Madmike1735 for trying.

My van has been misfiring randomly for a while now. I have changed the EGR valve, crank sensor, oil pressure sensor, gaskets (intake and valve covers), coil, wires, spark plugs, oil and oil filter. It idled real bad until I changed the PCV valve then it ran perfect for about fifty miles and all the sudden the oil light came on, engine light came on and the engine shut off. That is when I changed the oil pressure sensor and I was able to turn the engine over. But not it is misfiring very badly and once put into drive it shut off once given gas.
Does anyone have a solution?

I have checked the codes multiple time. I only receive the generic code P-03000 Cylinders 1-10. I only have six cylinders and it shows up 1-6 times. It never gives me a cylinder exactly.
The van sat for four years but was turned over regularly to keep fluids flowing and the battery normal.
Does anyone think I could have a clog in my fuel system (even though I am getting fuel but most of it is being spit out of the tail pipe unburned due to misfire)?
It rough idles now in park or neutral but in gear it stalls nearly moments after shifted into gear or reverse.
Also, I have an inkling that it might be internal. Can anyone confirm my ideas?

Thank you for that. I didn’t think to check the coolant sensor. That does make sense it would burn richer if it was thinking it was colder. I also am going to do a compression test on the motor to see if it is an internal issue because I think there might be a spring broken or a rod bent maybe. Also I’m gonna check the fuel pump as well as the oil pump. It seemed odd the oil pressure light turned on moments before the motor died. I’m also in the process of replacing most if not all sensors sense I found a lot of corrosion and brittleness to a lot of the sensors. I am in Las Vegas so the heat could have just eroded the sensors sitting in the desert sun for 4 yrs.
I will post an update once I have completed said obstacles.
Thank you again.

Update: so it turns out it was the very first thing I thought it was. My ECU fried out. Ordered a new one and placed it in and the van started up and now drives like new. Thanks you for the advice and support.