The manual does not state specifically what is done when you program the DME. It does need to be programmed but without the detail about what is done during the programming I can't answer that.
As you can see from the attachment the immobilizer system is part of the programming but this is normally just a back up of the information and does not require to be done in order to start the vehicle.
So to answer this question, I think you will need to call a dealer and ask one of the technicians this question. I have not replaced one of these with a used unit so I don't know for sure.
Sorry I can't answer that but I don't want to tell you that it can be used and then be wrong. Nor do I want to be on the safe side and say it can't be used and you spend more money then you need to.
Image (Click to make bigger)
Thursday, December 3rd, 2020 AT 12:11 PM