Hi,
That is a tough call. It is really based on how dirty the transmission fluid is at this point. If it is black and smells, new fluid could lead to a slip by cleaning the clutches. As far as the differentials, I can't imagine it would hurt servicing them. Actually, it may be a good idea.
Here is a link that shows how it's done:
https://www.2carpros.com/articles/differential-service
Now, based on which differentials you have, you will need to get the correct fluid. Here is all the technical info for fluid types and capacity:
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2006 Ford Truck F 350 4WD Super Duty V8-6.0L DSL Turbo VIN P
Fluid Types and Capacities
Vehicle Maintenance Fluids Fluid - Differential Specifications Fluid Types and Capacities
FLUID TYPES AND CAPACITIES
Fluid Types
Differential Fluid Type
FRONT AXLE LUBRICANT SPECIFICATIONS
Motorcraft SAE 80W-90 Premium Rear Axle Lubricant
Ford Part Number .................... XY-80W90-QL
Ford Specification .................... WSP-M2C197-A
REAR AXLE LUBRICANT SPECIFICATIONS
DANA 80
Motorcraft SAE 75W-90 Synthetic Axle Lubricant
Ford Part Number .................... XT-75W90-QLS
Ford Specification .................... GL-5
DANA S110/S130
Motorcraft SAE 75W-140 Synthetic Rear Axle Lubricant
Ford Part Number .................... XY-75W140-QL
Ford Specification .................... WSL-M2C192-A
Ford 10.50 Inch Axle
Motorcraft SAE 75W-140 High Performance Rear Axle Lubricant
Ford Part Number .................... XY-75W140-QL
Ford Specification .................... WSL-M2C192-A
NOTE: Add 8 oz. (236 ml) of Additive Friction Modifier XL-3 or equivalent meeting Ford Specification EST-M2C118-A for complete refill of limited slip Ford axles. Ford design rear axles contain a synthetic lubricant that does not require changing unless the axle has been submerged in water.
Capacities
FRONT AXLE LUBRICANT CAPACITY
DANA Super 60 .................... 3.02 Liters (6.38 pints)
REAR AXLE LUBRICANT CAPACITY
Dana 80
Conventional and Truetrac .................... 4.0 Liters (8.5 pints)
Trac-Lok* .................... 3.8 Liters (8.0 pints)
*First fill the axle with 0.2365 liters (0.5 pints) of Additive Friction Modifier C8AZ-19B546-A or equivalent meeting Ford specification EST-M2C118-A.
Dana S110 and S130
Capacity .................... 6.6 Liters (14 pints)*
*The lubricant capacity will vary depending upon the housing mounting angle. The capacity given is for an angle of 4 degrees. A lubricant level close enough to the bottom of the fill hole to be seen or touched is not sufficient. The lubricant must be level with the fill hole.
Ford 10.50-inch Ring Gear
10.50 Inch Axle (1) .................... 3.3 Liters (6.9 pints)
(1) Add 8 oz. (236 ml) of Additive Friction Modifier XL-3 or equivalent meeting Ford Specification EST-M2C118A for complete refill of limited slip Ford axles. Ford design rear axles contain a synthetic lubricant that does not require changing unless the axle has been submerged in water.
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I hope this is helpful. Let me know if you have other questions.
Take care,
Joe
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Monday, January 25th, 2021 AT 7:19 PM