After replacing fuel injectors there are multiple misfires on cylinders one and four?

What was the reason for replacing the injectors? Misfires or something else? If the misfires came after the injectors were replaced, are they the same flow rate as the stock parts? If not it's likely that the higher fuel rate is causing the misfires. If they are the same as stock and are OEM parts, it's possible that they are faulty or that the connectors to them are damaged. To see which the easiest way would be to first test the injector resistance numbers, to do that without taking much apart, if you can remove the injector harness connections you can test resistance between the two pins on the injectors, they should read between 12 and 20 ohms if they are at least in spec, that doesn't mean they work but at least the coils conduct. Or you can go to the ECM and find the injector control pins in the connectors on the ECM. That would allow you to test the injectors and the connections at the same time. You just unplug the connectors at the ECM and test the wiring and injectors at the same time. If you find 12-20 ohms at the connectors the wiring isn't the problem, if the connections show open then either a bad injector or the connector to it.