Hello, do you notice this misfire more under certain conditions, engine cold, under a load such as getting on the highway, etc? Have you had the engine computer scanned for misfire or any other diagnostic trouble codes? Do you think this is more rough running in drive than in neutral? And one last question, have you taken a look at the throttle body opening for carbon build up on the throttle plates? Just asking because there is a Technical Service Bulletin (TSB) on an ECM update for throttle body contamination. Another TSB on rough engine idle in Drive which may be worse with the a/c on due to load and cold engine. This is where there are no faults found with the Ignition System or Fuel related issue. I'll post both of those below in a few minutes.
Since you have replaced so many components already, I would recommend making sure all the Fuel Injectors have power and are being controlled by the ECM, both of these can be checked with a 12v test light.
There is another test you can do which has to do with disabling fuel injection and cranking the engine over to listen to the cranking cadence, and it can help determine if there is a compression issue with one of the cylinders.
Any other details you can give will help.
Unfortunately, the 2nd TSB (pages 3 and 4) ended in 2015. But it really shouldn't have been, it has to do with internal contamination of the electrical contacts inside the electronic throttle body which can make a rough running condition because the engine computer is in control of the throttle body, there is no cable, it's a drive by wire system.
https://www.2carpros.com/articles/how-to-test-a-fuel-injector
https://www.2carpros.com/articles/how-to-check-for-ignition-spark
https://www.2carpros.com/articles/how-to-test-an-ignition-system
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Friday, June 24th, 2022 AT 6:31 PM