going down the road shifted into second and it shut off?

Yep, it sounds like the battery has shorted out, I would remove the battery and install a new one.

This guide can help:

https://www.2carpros.com/articles/how-to-replace-a-car-battery

Please go over this guide and report back.

I replaced the battery. No change. I went through all the grounds and found they all had continuity. If you jump the starter solenoid it cranks over but doesn’t fire. I replaced the ignition control module and ignition switch with the same results. I’m eventually going to replace the wiring harness but think it might be sooner rather than later.

Did the sparking stop occurring? It sounds like the ignition module is out, does the system have spark? This video can help you test it:

https://youtu.be/baq_aEWNQ0Y

Please go over this guide and report back.

It has spark. I ran a new wire from the battery to the ignition and everything but the headlights and tail lights work.

I would check the fusible links at the starter solenoid. Pull on the link to see if they are broken. Let me know.