1998 Chevy Cheyenne Engine stalling when accelerated

Does this motor have a carburetor or a throttle body? Carburetors are not stock on these engines. Pull all the plugs and tell me what they look like.
Is this motor fuel injected? Is it a Vortec? Does the exhaust seem to be restricted?

These trucks have a few common problems. First of which is the coil wire grounding out on the transmission dipstick tube. Second is a weak volume from fuel pump, to test this you will need a dc amp meter(you can purchase one for about ten bucks) with meter on dc amp 10amp scale put one side to positive side of battery and the other side to the fuel pump test lead(this is either on passengers side by firewall, it will be a single wire with a pig tail at the end usually red or gray colored wire, or its located at the drivers side at the under hood junction block you will see the pig tail) you should have at least 9 amps minimum(were ideally looking for 10 amps. Not overlooking the obvious when was the last time she was tuned with new wires and cap and rotor? Get back to us.

I would definitely start with a complete tune up, it needs it. Bottom line is I think your going to find that you need a tune up and or fuel pump. Let us know

I agree, a tune up cannot hurt. Be sure to use A/C Delco plugs and wires. Do not make the mistake and put any other brand plug or wire on this engine.
Another common problem with this engine is the fuel pressure regulator and clogged up injectors.

The tank pressure sensor is located on top of the fuel pump assembaly. Right next to where the fuel pump electrical connector plugs in. There is a three wire connector for the sensor. You have to drop the tank to get to this sensor. P0452can also be a bad gas cap--believe it or not. Try changing the cap first.
The pressure regulator is located under the UPPER intake manifold and connects to the fuel bowl (where all of the injectors are). You must remove the plastic intake cover to access it.

Smilincro I think werre onto something here. I remember back in the days at the dealership I had a blazer intermittently dying while driving and what it ended up being is the fuel tank pressure sensor. I agree these are not common to go bad and a loose gas cap most often causes this code. If the sensor is actually bad it will bring down the map sensor voltage because it shares the same 5 volt reference. Hence causing a severe hesitation. You can check it for sure with a scanner and with the gas cap open it should read about 5 volts. If it reads below 4 volts then thats your hesitation