2000 BMW 528 Revs in Park but won't accelerate in drive pro

I have a '00 e39 528i, with 140k that needs some help figuring out this problem. I hope someone that had the same issues and was able to properly diagnose and fix it can share their experience.

I am thinking Vacuum issue or Catalytic Converter. (Recently I have been driving great distances.125 miles round trip to work 3 days a week. And using the Step/Tip Tronic feature pretty regularly on the highway to pass people. Did the Higher revs perpetuate an issue with the CAT and blow it out inside?)

Symptoms:
-Won't start unless I give it a little bit of gas.
-In neutral and park, it revs just fine. Give it gas and it responds as it should
-In drive, I press the gas and nothing. Slow sputter. Gets up to speed after a very. Very. Long time.
-I have to throw it into Tip/Step Tronic mode to get it up to speed in a decent amout of time.
-Will get up to about 80 miles an hour.
-Gas mileage has dropped by more than half!
-For a long time the Secondary Air Pump makes the sound of ajet engine every morning for 2 minutes. (I live in S. Florida. Freezing temps not an issue for the water in it)

Codes pulled:
First set of codes pulled were as follows:
p1250.P0302.P1580.P0306.P0303.P1423.P1421.P0430.P0300
Reset and today these codes pulled however engine light not on:
p1250.P0101.P1770

Things I fixed so far:
Took off and sprayed:
-MAF
-Throttle control
-Idle control

-Bought and installed new Fuel Pressure Regulator

-Took off and drained Secondary Air Pump, drained a small bit of water, sprayed with PB Blaster, Sprayed electrical connections and reinstalled.

Same issues persist after all that was done. I was told that a bad Secondary Air Pump can cause a Catalytic Converter to go after some time. If so that would make sense here for the Pump has been making that annoying noise for about a year now.

If someone knows Catalytic Converters. Will it cause this issue?

Reasons I want to rule out a fuel issue is that it revs fine in neutral and park. It has the issue when in drive and a serious issue when going slow up my parking garage ramp, almost comes to dead stop. However, I can manipulate the speed. Get faster quicker when I throw it into tiptronic mode and downshift.

Oddly. When the issue was first noticed 2 things were worth noting:
1. I noticed the wire harness that goes into the engine oil tank under the car was dislodged.
2. I had started using the Tip/Step tronic feature for the first time. Alot. I drive to work 65 miles each way everyday 3 days a week and its more fun to use it on the highway passing people.
- Car has 140k miles on it and I have not used this feature in the past. I am leaning towards this being the accelerant of the problem.

Hopefully I have enough info that someone who knows or has had same issue can help me. Please don't just randomly throw out conspiracy theories. Thanks for the help!