2008 Ford F-150 overheating

Running for 2 hours where/how? Freeway? City/stoplights? Combination? No difference?

Check the coolant. It should not be rusty. When was the last time you flushed the cooling system? This is going to suck, but see if turning on the heater helps. Check the oil. Does it look like a milkshake or oil? Wipe your finger along the dipstick and feel the oil between your fingers. Does it feel runny like water or is there some thickness to it? Got oil gauge? What's it say? Pop the radiator/overflow bottle top and start the engine and let it warm up completely. Then check to see if you can see coolant flowing. If not, you've got either a bad thermostat or water pump. Look at the water pump and just under the snout of it. Do you see any leakage that's beyond a slight seepage (which is often normal)? If so, replace it and the thermostat, plus the coolant. Eyeball the radiator. See if anything is clogging the cooling tubes and blocking airflow through it. If so, CAREFULLY clean it out.