Engine will not start

My 2000 S10 will not start. This is what I have done so far
1. Used starting fluid to see if I had spark- tried to start- have spark
2. Checked feul filter. Installed a new one even though the old one seemed ok. Still nothing.
3. Checked the fuel relay- seems fine and can hear the fuel pump when turnig key on.
4. Started to disconnect fuel filter (gas tank side) and a considerable amount of pressure was in the line.
I can only assume a plug between the fuel filter and the thottle body or the throttle body itself is totally pluged. That seems unlikely but am I missing something? Where do I go from here.