I am following your how to video for the 347 stroker engine?

You would most likely want to lower the compression ratio a bit with forced induction. Also you need to open the piston rings in accordance with the manufacturer for forced induction. I would also select a different camshaft that is going to work better with boost. But everything else would work great. The entire rotating assembly is forged so it can handle the heat and power.

I have never done custom lowering on a truck but all the ones I have seen have been 2wd and a ton of custom fabrication.

For those Fords I have only ever seen centrifugal super chargers on them and it is specific to your belt routing and intake manifold. So something out of this list might work for you https://www.summitracing.com/search/make/ford/engine-size/5-0l-302/engine-family/ford-small-block-windsor?N=part-type%3Asuperchargers-centrifugal-style-kits_superchargers-roots-style-kits&kr=supercharger&page=1

Thank you for watching and using 2CarPros!

The first thing is to decide what you want out of the engine. For a supercharger the pistons, rings, bore tolerances, camshaft, compression ratios, port design, combustion chambers and more all need to be tailored to the expected power level and the expected boost if you want the engine to be reliable. You also need to decide what it will be used for. You say you want to lower it, if it's going to be more cruise oriented the engine is going to be different than if you want to say drag and drive. Those big lumpy cams are fun to hear but they can be a real bear to drive as a streetcar. As for the actual modifications, set down and write out what you expect from the engine, you will want to drop the idea of both a blower and a turbo, they don't work well together in reality. For instance, the boost requires lower compression because the boost makes the dynamic compression higher. Then you need a different cam because now you have boost to push the charge into the engine, that also lets you use a smaller valve and a different combustion chamber design due to the boost and lack of the need to pull in the charge like a naturally aspirated engine. That is why you need to write down real expectations, then talk to the folks who make the parts. See what they recommend to achieve your goal.
As for lowering the truck, you would be better off getting a 2WD as the base, there is still going to be a lot of custom fabrication even then, but you won't also need to modify the frame as much and build a complete front suspension to drop it. You are looking at a lot of work to build it to work and be safe.