Car is getting no power and Battery Fuse keeps breaking

Hi everyone, im new here. I have a 1993 Acura Vigor GS, with about 155k miles on it. The problem started when I left my lights on, which caused the battery to die. After jumpstarting it, it drove me home o.K. But when I started it again after I charged the battery, it just died.

Now when I try to start it it does nothing. No dash lights or sound. I then found out that the main battery fuse (100 amps) had blown. When I replaced it, it broke again right when I reconnected the battery. I have no idea what is causing this, Anyone have any suggestions?

Thanks!
- Nick