1999 Acura TL has a bad miss

When was the last tune-up?

Scan your computer for code/s and you might want to check and test the following below:

Engine misfiring can be caused by worn or fouled spark plugs, a weak spark (weak coil, bad spark plug wire), loss of compression, vacuum leaks, anything that causes an unusually lean fuel mixture (lean misfire), an EGR valve that is stuck open, dirty fuel injectors, low fuel pressure, or even bad fuel.