Engine misfire cruising on the highway

Hi thank you! I replace the fuel pressure sender, map sensor, all four O2 sensors, fuel pressure reading is 50psi, spark plugs changed 3000 miles ago, I put a computer on it and it said my barometric pressure voltage is 4.25 which I think its suppose to be reading.5 volts. So i'm very lost can you help me? Oh yeah it idles with a little miss and when I first get on the fuel slowly it bucks and chokes misses bad. Then when I kick it down to the next gear it runs fine. But when its in overdrive going up a hill it does the same thing until it kicks into the lower gear. Any help would be appreciated.

Can anyone help please only vehicle I have to get to work and pick up the kids from school

At idle or on the throttle

No not at all. Im lost.

No not at all. So it's at max all the time thinking it needs max fuel.

5.3

I don't either. Some one said it was run by the map sensor. But I put in a new map. And did not change anything.

I will have to check again lol

1.25 v

1.25