Hi jpost,
Here is a description of the code and explanation of the problem
DTC P0300: RANDOM MISFIRE AND ANY COMBINATION OF THE FOLLOWING:; DTC P0301: NO. 1 CYLINDER MISFIRE DETECTED; DTC P0302: NO. 2 CYLINDER MISFIRE DETECTED; DTC P0303: NO. 3 CYLINDER MISFIRE DETECTED; DTC P0304: NO. 4 CYLINDER MISFIRE DETECTED; DTC P0305: NO. 5 CYLINDER MISFIRE DETECTED; DTC P0306: NO. 6 CYLINDER MISFIRE DETECTED
NOTE:
Before you troubleshoot, record all freeze data and any on-board snapshot, and review the general troubleshooting information.
If the misfire is frequent enough to trigger detection of increased emissions during two consecutive driving cycles, the MIL will come on, and DTC P0300 (and some combination of P0301 through P0306) will be stored.
If the misfire is frequent enough to damage the catalyst, the MIL will blink whenever the misfire occurs, and DTC P0300 (and some combination of P0301 through P0306) will be stored. When the misfire stops, the MIL will remain on.
Troubleshoot the following DTCs first, if any of them were stored along with the random misfire DTC(s) (Because parts can sometimes fail without setting DTCs, you should also do a physical inspection of the below systems.
Check out this guide
https://www.2carpros.com/articles/engine-misfires-or-runs-rough
P0107, P0108, P1128, P1129: Manifold absolute pressure (MAP) sensor
P0171, P0172, P0174, P0175: Fuel system
P0335, P0339, P0385, P0389: Crankshaft position (CKP) sensor A/B
P0340, P0344: Camshaft position (CMP) sensor
P0401, P0404, P0406, P2413: Exhaust gas recirculation (EGR) system
P0506, P0507: Idle control system
P2646, P2647, P2648, P2649: VTEC system (J35A9 engine)
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Monday, January 26th, 2009 AT 12:54 PM